|
KMID : 0614620080520050325
|
|
Korean Journal of Gastroenterology
2008 Volume.52 No. 5 p.325 ~ p.328
|
|
|
Development of Clevudine Resistance after Switching from Lamivudine in a Patient with Chronic Hepatitis B
|
|
Koh Kyung-Hyun
Kang Chang-Jun
Kim Dong-Hoon
Choi Yong-Won
Kim Moo-Jung
Cheong Jae-Youn
Cho Sung-Won
|
|
|
Abstract
|
|
|
|
Clevudine is a nucleoside analog of the unnatural β-L configuration which has potent antiviral activity against hepatitis B virus (HBV). Clevudine is expected to have similar pattern of resistance profile as lamivudine. However, there was no report on the mutation associated with clevudine resistance in patients with chronic hepatitis B. We report a case of young male patient with chronic hepatitis B who presented with clevudine resistance. The patient had received lamivudine therapy for 5 months with reduced serum HBV DNA levels. Then, lamivudine was switched to clevudine monotherapy. After the 6 months of clevudine therapy, the patient developed virologic breakthrough (＞1.0×108 copies/mL) as well as biochemical breakthrough, which was associated with the presence of rtM204I plus rtL80I mutant. After switching from clevudine to adefovir, the viral load decreased with biochemical improvement.
|
|
|
KEYWORD
|
|
|
Chronic hepatitis B, Clevudine, Resistance
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
   
|